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  • Title: Sequential treatment of deep leg vein thrombosis with porcine plasmin and low dose streptokinase.
    Author: Marbet GA, Eichlisberger R, Duckert F, de Silva MA, Biland L, Widmer LK, Ritz R, Schmitt HE.
    Journal: Thromb Haemost; 1982 Oct 29; 48(2):190-5. PubMed ID: 6217581.
    Abstract:
    Sequential treatment of deep leg vein thrombosis with porcine plasmin and low dose streptokinase (10,000-20,000 U/h) produces strong systemic fibrinolysis as demonstrated by the sustained decrease of euglobulin lysis time, of thromboplastin time values in percent, fibrinogen and factor V levels. There is a statistically significant negative correlation between thrombolytic results and euglobulin lysis time. Treatment period below 3 days are unlikely to give satisfactory results. Occluded vein segments with an apparent median age of 4 days including thrombi older than 10 days (20% of cases) are cleared with an average chance of 50%. Complete dissolution of all thrombi proximal to the crural veins has been demonstrated in 47/114 = 41.2%, some thrombolytic effects in 31/114 = 27.2% and treatment failure in 36/114 = 31.6%. The data favour laboratory monitoring of thrombolytic therapy.
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