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  • Title: [Inhibition of prostaglandin synthesis by (phenylthio-4 phenylamino)-2 nicotinic acids].
    Author: Damas J, Deflandre E, Bethegnies G, Gesquière JC.
    Journal: C R Seances Soc Biol Fil; 1982; 176(4):558-62. PubMed ID: 6217877.
    Abstract:
    In the rat, (phenylthio-4 phenylamino)-2 nicotinic and [(chloro-4 phenylthio)-4 phenylamino]-2 nicotinic acids inhibit the hypotensive prostaglandin-mediated action of arachidonic acid. They inhibit also the formation from arachidonic acid, of prostaglandin-like substances by chopped rat lungs and of malonaldehyde by rat platelets. They are prostaglandin synthetase inhibitors, three to ten times less active as indomethacin.
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