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  • Title: Assay of some endogenous and synthetic sex steroids for tumor-initiating activity in rat liver using the Solt-Farber system.
    Author: Schuppler J, Dammé J, Schulte-Hermann R.
    Journal: Carcinogenesis; 1983; 4(2):239-41. PubMed ID: 6218932.
    Abstract:
    Endogenous (estradiol-17 beta; progesterone) and synthetic (ethinyl estradiol; cyproterone acetate; norethindrone acetate; norethynodrel) sex steroids were evaluated for tumor-initiating activity in the rat liver using the Solt-Farber system. All steroids were negative. This provides further evidence that tumor formation in long-term rodent bioassays by these compounds may be due to epigenetic mechanisms.
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