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  • Title: Cellular basis of hyper IgM immunodeficiency.
    Author: Pascual-Salcedo D, de la Concha EG, Garcia-Rodriguez MC, Zabay JM, Sainz T, Fontán G.
    Journal: J Clin Lab Immunol; 1983 Jan; 10(1):29-34. PubMed ID: 6219226.
    Abstract:
    Six patients with primary hypogammaglobulinaemia and hyper IgM were studied. All showed very low serum IgG and IgA concentrations. The in vitro pokeweed-mitogen (PWM)-induced immunoglobulin (Ig) production, including IgM, by their peripheral blood lymphocytes was low. Even when patients' B cells were cocultured with normal T cells, IgM production did not reach normal levels. These results and studies of Ig class on the surface of B lymphocytes point to a maturation arrest of these cells. T cells from all but one patient helped very little Ig production by patients' or normal B cells. Similar numbers of these T cells did not suppress Ig production by normal T plus B cells. Therefore a defect in T cell help for IgM, IgG and IgA was seen in most patients, in addition to the B cell abnormality.
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