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  • Title: Mutagenesis resulting from depurination is an SOS process.
    Author: Schaaper RM, Glickman BW, Loeb LA.
    Journal: Mutat Res; 1982 Nov; 106(1):1-9. PubMed ID: 6219285.
    Abstract:
    When bacteriophage phi X174 am3 DNA depurinated in vitro is transfected into E. coli spheroplasts prepared from bacteria previously exposed to UV light, a strong mutagenic response is observed. This mutagenic response does not occur in spheroplasts derived from pre-irradiated bacteria carrying defective recA, recF or umuC genes. These findings indicate that mutagenesis at apurinic sites is an SOS-dependent process. The mutagenic response is not dependent on the multiplicity of transfection. This suggests that mutagenesis is not mediated by recombination.
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