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  • Title: [Acute anuric hemolysis caused by antiajmaline antibodies].
    Author: Habibi B, Blériot JP, Pinsard D, Bretagne Y, Guérin A, Carlet J.
    Journal: Presse Med; 1983 Feb 19; 12(8):513-5. PubMed ID: 6219361.
    Abstract:
    In a 32-year old woman under ajmaline therapy for cardiac arrhythmia, a sudden episode of acute haemolytic anaemia and renal failure led to the identification of a potent agglutinating, haemolysing and lymphocytotoxic antibody specific to ajmaline and cross-reacting with quinine and quinidine. The immunological features of the antibody and the pathophysiological mechanism of blood cell destruction are presented, together with a brief synopsis of drugs incriminated so far in the induction of specific antibody formation and immune haemolytic anaemia.
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