These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Studies of human T gamma cells: division of a T gamma subset in normal and leukemic cells by using anti-T gamma-CLL heteroantiserum.
    Author: Konishi I, Machii T, Hiraoka A, Kanayama Y, Taniguchi N, Tamaki T, Yonezawa T, Kitani T.
    Journal: Biken J; 1982 Sep; 25(3):101-9. PubMed ID: 6219661.
    Abstract:
    A specific heteroantiserum was prepared against the leukemic cells from a patient with T-derived chronic lymphocytic leukemia (T-CLL). The anti-serum was absorbed with cells of a morphologically different type from another patient with T-CLL. Both the immunizing cells and absorbing cells had Fc receptor for IgG (Fc gamma R), so the former case was named T gamma-CLL type 1, and the latter T gamma-CLL type 2. This antiserum, termed anti-T gamma-1, reacted with 19% of normal peripheral blood T lymphocytes, but not with non-T lymphocytes or monocytes. The T lymphocytes in the blood that reacted to anti-T gamma-1 were 72% of the T gamma cells. Anti-T gamma-1 also reacted to 60-78% of the thymocytes. Except for T gamma-CLL type 1 cells, anti-T gamma-1 did not react with various types of leukemia cells from lymphoid malignancies, myelogenous leukemias and monocytic leukemias. Studies on the relation between anti-T gamma-1 and OKT8 monoclonal antibody revealed that anti-T gamma-1 reactive (anti-T gamma-1+) cells and OKT8+ cells largely overlapped, but they were different in part. More interestingly, OKT8 inhibited Fc gamma R binding, but anti-T gamma-1 did not. These results indicate that anti-T gamma-1 is useful for detecting a certain subset of T cells and for classifying lymphoproliferative disorders.
    [Abstract] [Full Text] [Related] [New Search]