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  • Title: [Penetration of mezlocillin and oxacillin into the glandular and adipose tissue of the breast after simultaneous intravenous infusion. A pharmacokinetic study].
    Author: Bordt J, Holzgreve W, Wagner H, Adam D.
    Journal: Geburtshilfe Frauenheilkd; 1983 Jan; 43(1):18-9. PubMed ID: 6219911.
    Abstract:
    The concentrations of mezlocillin and oxacillin were measured after simultaneous intravenous infusion of 4 and 2 g respectively in serum, fat and mammary gland tissue of 35 patients. The maximum mean concentrations of mezlocillin were measured in serum with 281 micrograms/ml and in fat with 38 micrograms/g after the end of the infusion and in the mammary gland with 52.3 micrograms/g after 90 minutes. Mezlocillin concentrations of less than or equal to 2.0 micrograms/ml and g respectively were found after 6-8 hours after the end of the infusion. The maximum mean concentrations of oxacillin were measured in the serum with 107.8 micrograms/ml also after the end of the infusion, declining to levels less than or equal to 2.0 micrograms/ml within 6 hours. Measurable oxacillin-concentrations could not be found in the fat and in the tissue of mammary gland with the chosen dose. The clinical relevance of the results is discussed.
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