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  • Title: Proteoglycan alterations in rabbit knee articular cartilage following physical exercise and immobilization.
    Author: Tammi M, Säämänen AM, Jauhiainen A, Malminen O, Kiviranta I, Helminen H.
    Journal: Connect Tissue Res; 1983; 11(1):45-55. PubMed ID: 6221879.
    Abstract:
    Rabbit knee articular cartilage was studied after the joint was submitted to immobilization, running or increased weight bearing for 24-27 days. Immobilization with a plastic splint reduced the fraction of proteoglycans not extractable with 4 M guanidinium chloride (GdnHCl). In the immobilized joints the chondroitin sulfate content was elevated as calculated from the galactosamine/glucosamine ratio. The ability of these proteoglycans to reform aggregates with endogenous hyaluronic acid in Sepharose CL-2B chromatography was reduced. Increased exercise was associated with an elevation of proteoglycans extractable with 4 M GdnHCl. The increased weight bearing occurring in the contralateral knee elevated the content of proteoglycans not extractable with 4 M GdnHCl. Other effects of weight bearing included increased glucosamine concentration, suggesting accumulation of keratan sulfate-rich proteoglycans, and an elevated hydroxyproline concentration.
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