These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Time-courses of p-CPA-induced depletion of brain serotonin and muricidal aggression in the rat.
    Author: Valzelli L, Bernasconi S, Dalessandro M.
    Journal: Pharmacol Res Commun; 1983 Apr; 15(4):387-95. PubMed ID: 6223323.
    Abstract:
    p-Chlorophenylalanine is known to selectively decrease brain serotonin and to induce muricidal aggression in previously docile rats. With regard to the substance's relatively time-limited effect on brain serotonergic system, the neurochemical activity of p-CPA on tryptophan, serotonin and 5-hydroxyindoleacetic acid on seven discrete areas of the rat brain is studied in parallel to the time-course of muricidal aggression induced by the drug. Evidence indicates that, following the disruption of brain serotonergic inhibitory control, muricidal aggression becomes a stable behavior, probably on account of its self-reinforcing property.
    [Abstract] [Full Text] [Related] [New Search]