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  • Title: Rat heart mitochondria release adenosine.
    Author: Bukoski RD, Sparks HV, Mela LM.
    Journal: Biochem Biophys Res Commun; 1983 Jun 29; 113(3):990-5. PubMed ID: 6223636.
    Abstract:
    Isolated rat heart mitochondria release adenosine under specific conditions. Lowest adenosine release occurs at 4 degrees C while highest release occurs in the presence of pyruvate + malate or rotenone at 30 degrees C. The release is attenuated during state 3 respiration, in the presence of atractyloside or in the presence of 1799. Oligomycin only partially decreases adenosine release. Release is unaffected by 200 microM Ca++ and is independent of oxygen concentration as low as 2 microM. The data are consistent with the hypothesis that adenosine is released from mitochondria via the adenine nucleotide transporter and the release is regulated by the intramitochondrial ATP to ADP ratio.
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