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  • Title: A selective effect upon IgG synthesis by T gamma lymphocytes and their products in man.
    Author: Warrington RJ, Olivier SL, Sauder PJ, Rutherford WJ.
    Journal: Clin Immunol Immunopathol; 1983 Mar; 26(3):415-22. PubMed ID: 6223749.
    Abstract:
    Depletion of T lymphocytes possessing receptors for IgG (T gamma cells) from peripheral blood lymphocytes (PBL) results in enhanced pokeweed mitogen (PWM)-induced IgG synthesis and secretion as compared to IgM. Concanavalin A (Con A) stimulation of T gamma cells causes release of soluble mediators able to suppress immunoglobulin synthesis by PWM-activated PBL. Such factors cause concentration-dependent selective suppression of IgG synthesis. The mediators act upon T gamma cell-depleted lymphocyte populations, also preferentially suppressing the IgG PFC response while leaving the IgM response relatively intact. Thus T gamma cells and their products selectively affect IgG synthesis in vitro.
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