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  • Title: Relationship between T cell subsets and suppressor cell activity in chronic hepatitis B virus (HBV) infection.
    Author: Barnaba V, Musca A, Cordova C, Levrero M, Ruocco G, Albertini-Petroni V, Balsano F.
    Journal: Clin Exp Immunol; 1983 Aug; 53(2):281-8. PubMed ID: 6224609.
    Abstract:
    The relationship between T cell subset, as defined by monoclonal antibodies, and suppressor cell function, using a short lived suppressor cell assay, was studied in 38 chronic hepatitis B virus (HBV) carriers and in 32 patients with HBsAg negative chronic active hepatitis (CAH). Patients with HBV chronic infection showed an absolute reduction in the OKT4 positive subset and a significantly decreased OKT4/OKT8 ratio, as compared with healthy controls. Patients with anti-nuclear antibodies (ANA) and anti-smooth muscle antibodies (ASMA) positive CAH with or without antibodies to HBV antigens, namely anti-HBs and anti-HBc, demonstrated a significant reduction in cytotoxic/suppressor T cells and an increased helper/suppressor ratio. A negative correlation between suppressor index (SI) and OKT4/OKT8 ratio (P less than 0.01), and a positive correlation between SI and OKT8 positive cells absolute number (P less than 0.01) were also observed.
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