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  • Title: Na+-coupled transport of melibiose in Escherichia coli: analysis of mutants with altered cation specificity.
    Author: Tsuchiya T, Niiya S.
    Journal: Tokai J Exp Clin Med; 1982; 7 Suppl():61-4. PubMed ID: 6225227.
    Abstract:
    Melibiose transport via the melibiose transport system of Escherichia coil utilizes either H+ or Na+ as a coupling cation. This system may represent a evolutional transition state between H+-substrate cotransport (bacteria type) and Na+-substrate cotransport (animal type). We have isolated mutants which showed altered cation specificity for melibiose transport. The melibiose carrier of the mutants has lost the ability to recognize H+. This communication describes the properties of the melibiose transport system and the properties of the mutants.
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