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  • Title: Response of generalized granuloma annulare to high-dose niacinamide.
    Author: Ma A, Medenica M.
    Journal: Arch Dermatol; 1983 Oct; 119(10):836-9. PubMed ID: 6225398.
    Abstract:
    A patient with generalized granuloma annulare experienced resolution of her lesions after six months of treatment with 1,500 mg/day of niacinamide. Niacinamide seems to be a reasonably safe drug that, even at relatively high doses, is associated with a low incidence of side effects. The participation of a delayed hypersensitivity reaction in the pathogenesis of granuloma annulare and possible mechanisms involving niacinamide in this type of reaction are discussed.
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