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  • Title: Ceftazidime in patients with Pseudomonas infections.
    Author: Eron LJ, Park CH, Hixon DL, Goldenberg RI, Poretz DM.
    Journal: J Antimicrob Chemother; 1983 Jul; 12 Suppl A():161-9. PubMed ID: 6225762.
    Abstract:
    Ceftazidime was administered to 41 patients with serious infections caused by Pseudomonas aeruginosa (24 cases) and other bacteria (17 cases). The clinical response rate of pseudomonas infections (88%) was similar to that of other bacteria (94%) with microbiological eradication of 83% of initial pseudomonas isolates compared to 82% of non-pseudomonas strains. The development of resistance to ceftazidime during therapy was observed in 3 cases (Enterobacter agglomerans, Enterobacter cloacae, and Ps. aeruginosa), and superinfection by a resistant Enterobacter agglomerans occurred in one case. Adverse reactions of clinical significance included two cases of leukopenia and one case each of azotaemia, diarrhoea (Clostridium difficile toxin positive), and rash.
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