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  • Title: T-lymphocyte subpopulations in pregnancy.
    Author: Bolis PF, Franchi M, Guaschino S, Sampaolo P, Maccario R.
    Journal: Biol Res Pregnancy Perinatol; 1983; 4(3):107-9. PubMed ID: 6226323.
    Abstract:
    T-lymphocyte subpopulations were evaluated in 44 pregnant women at different stages of gestation by means of monoclonal antibodies. A total of 32 healthy women of the same age served as a control group. OKT3-positive cells (more than 95% of the circulating T-lymphocytes) decrease markedly in pregnancy between the 14th and the 28th week. Such a decrease seems to be due to a specific lowering in the number of OKT4-positive cells (which seem to represent helper T-lymphocytes). OKT8-positive cells (which seem to represent cytotoxic-suppressor T-lymphocytes) show no meaningful alteration. Possibly due to helper decrease, maternal immunity is impaired between the 14th and 28th week.
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