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  • Title: Comparison of acetylcholine sensitivity in asthmatics with negative and positive response to exercise.
    Author: Nagy L, Tóth A.
    Journal: Allerg Immunol (Leipz); 1983; 29(3):145-8. PubMed ID: 6227215.
    Abstract:
    Airways response to inhaled acetylcholine was studied in asthmatic patients with negative and positive response to exercise. The respiratory threshold of acetylcholine proved to be lower in exercise-responders. Mean value of the bronchoconstrictive dose of acetylcholine was found 72 +/- 78 micrograms in patients with positive, while 510 +/- 360 micrograms in those with negative response to exercise challenge. Our data seem to confirm previous hypotheses, i.e. that exercise-induced asthma is a phenomenon dependent on two factors: mediators generated during exercise (histamine, catecholamines, neutrophil chemotactic factor) and a vagal response from the bronchi.
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