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  • Title: [Characteristics of the androgenic function of steroid-producing glands of baboons in the metapyrone test].
    Author: Butnev VIu, Goncharov NP.
    Journal: Biull Eksp Biol Med; 1983 Nov; 96(11):99-102. PubMed ID: 6227350.
    Abstract:
    Experiments on adult and prepubertal male baboons were made to study and compare the androgenic function of the steroid-producing glands of monkeys in the metopyrone test. The content of the steroid compounds, testosterone, 5 alpha-dihydrotestosterone, delta 4-androstendione and dehydroepiandrosterone in the monkey blood was measured by radioimmunoassays. The content of 5 alpha-dihydrotestosterone in the blood of monkeys of both age groups did not undergo any significant changes throughout the whole experiment, whereas the content of testosterone and delta 4-androstendione rose to a greater degree in the blood of prepubertal animals. The concentration of dehydroepiandrosterone in the blood of prepubertal monkeys remained significantly elevated, even 3 days after the metopyrone administration. The reasons for age-associated differences in the hormonal response of the steroid-producing glands of baboons to metopyrone administration are discussed.
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