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  • Title: Resolution of etodolac and antiinflammatory and prostaglandin synthetase inhibiting properties of the enantiomers.
    Author: Demerson CA, Humber LG, Abraham NA, Schilling G, Martel RR, Pace-Asciak C.
    Journal: J Med Chem; 1983 Dec; 26(12):1778-80. PubMed ID: 6227748.
    Abstract:
    Etodolac, 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid, a clinically effective analgesic and antiinflammatory agent, has been resolved via a chromatographic separation of its diastereoisomeric esters with (-)-borneol. The effects of the enantiomers were studied in vitro on prostaglandin synthetase and on adjuvant-induced arthritis in rats. The biochemical and pharmacological results show that virtually all of the effects of etodolac are due to the (+) enantiomer.
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