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  • Title: Monoclonal antibodies to human leucocyte antigens in polymyositis and muscular dystrophy.
    Author: Rowe D, Isenberg DA, Beverley PC.
    Journal: Clin Exp Immunol; 1983 Nov; 54(2):327-36. PubMed ID: 6228350.
    Abstract:
    Biopsy specimens from patients with treated or untreated polymyositis and muscular dystrophy controls were examined by indirect immunoperoxidase staining with a panel of monoclonal antibodies to human leucocyte antigens. In untreated polymyositis, helper/inducer T cells were the predominant T cell subset. In treated cases few T cells were seen. Overall, few T cells were seen in dystrophic cases, most infiltrating cells being dendritic and lacking T cell antigens. Staining of sarcolemma with anti-HLA class 1 antibody is weak or negative except in areas adjacent to infiltrating leucocytes or where muscle fibre damage is apparent.
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