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  • Title: Insulin secretion: combined effects of phorbol ester and A23187.
    Author: Zawalich W, Brown C, Rasmussen H.
    Journal: Biochem Biophys Res Commun; 1983 Dec 16; 117(2):448-55. PubMed ID: 6229253.
    Abstract:
    The effect of the ionophore, A23187, and/or the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), on insulin secretion were compared with those of glucose. Glucose induces a biphasic pattern of insulin secretion; A23187 a comparable initial spike but no second phase; and TPA a slowly progressive increase. Combined A23187 and TPA evoke a pattern similar to that induced by glucose. Forskolin enhances both phases of glucose- induced and of TPA-A23187-induced insulin secretion. These results are interpreted in terms of a model of cell activation in which two branches of the calcium messenger system, the calmodulin branch and the C-kinase branch, control, respectively, the initial and sustained phases of insulin secretion.
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