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  • Title: Helper cell-independent clonal expansion of H-2D-restricted cytolytic T cells.
    Author: von Boehmer H, Kisielow P.
    Journal: Fed Proc; 1984 Feb; 43(2):268-70. PubMed ID: 6229423.
    Abstract:
    Cytotoxic T lymphocyte (CTL) clones of different phenotypes have been described: some need extrinsic growth factors for proliferation whereas others can be expanded by antigenic stimulation. Up to 40% of CTL clones obtained early during in vitro culture can be stimulated by antigen in the absence of extrinsic interleukin 2 (IL 2) whereas all late clones require exogenous IL 2. Early clones regularly change their phenotype, i.e., their growth becomes dependent on exogenous IL 2. We propose that the growth of Lyt-2+ cells restricted by class I major histocompatibility complex (MHC) antigen is essentially independent of growth factors produced by class II MHC antigen-restricted T helper cells but can be augmented by such factors, especially at later stages of antigen-induced differentiation.
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