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  • Title: Diethylstilbestrol exposure in utero and endometriosis in infertile females.
    Author: Stillman RJ, Miller LC.
    Journal: Fertil Steril; 1984 Mar; 41(3):369-72. PubMed ID: 6230258.
    Abstract:
    Endometriosis was found in 39% and in utero diethylstilbestrol (DES) exposure in 5% of 397 infertile women who had undergone laparoscopy and/or laparotomy among 750 consecutively evaluated infertile couples. Fifty percent of the DES-exposed infertile women also had endometriosis, similar to the 39% with endometriosis among non-DES-exposed women. Cervical stenosis was found in 25% of all DES-exposed patients and in 83% of those who had undergone cryocautery or conization. However, 40% did not have endometriosis. Thus, while the frequency of endometriosis and cervical stenosis is extremely high in infertile women exposed in utero to DES, a significant association beyond that found in non-DES-exposed patients could not be established. Some of the infertility may be associated with cervical stenosis alone. Endometriosis was found in 39% and in utero diethylstilbestrol (DES) exposure in 5% of 397 infertile women who had undergone laparoscopy and/or laparotomy among 750 consecutively evaluated infertile couples. 50% of the DES exposed infertile women also had endometriosis, similar to the 39% with endometriosis among non-DES exposed women. Cervical stenosis was found in 25% of all DES-exposed patients and in 83% of those who had undergone cryocautery or conization. However, 40% did not have endometriosis. Thus, while the frequency of endometriosis and cervical stenosis is extremely high in infertile women exposed to DES in utero, a significant association beyond that found in non-DES exposed women could not be established. Some infertility may be associated with cervical stenosis alone.
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