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  • Title: Lack of a T-cell dependent subpopulation of macrophages in (dichloromethylene) diphosphonate-treated mice.
    Author: Labat ML, Tzehoval E, Moricard Y, Feldman M, Milhaud G.
    Journal: Biomed Pharmacother; 1983; 37(6):270-6. PubMed ID: 6231061.
    Abstract:
    In Cl2MDP-osteopetrotic mice, one subpopulation of thioglycollate-induced peritoneal exudate macrophages (M phi) is missing. This subpopulation is precisely the one whose differentiation is known to be dependent on T-lymphocytes, as it is also missing in the athymic nu/nu mice. Cl2MDP-induced osteopetrosis being partially attributable to deficient osteoclastic bone resorption, raises the possibility that this missing M phi subpopulation might represent the precursors of osteoclasts. It is suggested from this work that the interplays between T-cells and M phi, so well known in immunity and inflammation, may also be relevant to osteoclastic differentiation and therefore, to bone remodeling.
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