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  • Title: [Transitory leukemoid reaction with regressive clonal course in a mongoloid newborn infant].
    Author: Weill J, Lai JL, Zandecki M, Blanckaert D, Ponté C.
    Journal: Arch Fr Pediatr; 1983 Dec; 40(10):785-7. PubMed ID: 6231900.
    Abstract:
    A neonate with Down's syndrome presented with partial blast infiltration that spontaneously regressed without relapse at age 6 months. Sequential cytogenetic studies of cells in blood and bone marrow initially showed presence of a clone with 46 chromosomes and reciprocal translocation of chromosomes 5 and 7. This clone and the hematologic abnormality later disappeared simultaneously. Two explanations may be suggested: a defect in the maturation of normal blasts due to abnormal environment in the bone marrow, or an intrinsic abnormality of hematopoietic cells. The case reported would favor the second hypothesis.
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