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  • Title: [Participation of the IgE receptor in the toxicity of blood platelets against schistosomes].
    Author: Joseph M, Ameisen JC, Kusnierz JP, Pancré V, Capron M, Capron A.
    Journal: C R Acad Sci III; 1984; 298(3):55-60. PubMed ID: 6231973.
    Abstract:
    Human blood platelets, incubated with the serum from patients with schistosomiasis or allergic asthma, became cytotoxic for schistosome larvae, in an allergen-specific mechanism linked to surface bound IgE on platelets. Cytotoxic factors, among which oxygen metabolites might be involved, were able to kill schistosomula through platelet-retaining filters. Flow cytometry showed that platelets bearing IgE receptors represented a subpopulation, the percentage of which significantly increased in patients with high levels of circulating IgE.
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