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  • Title: A quantitative comparison of T-cell subsets in Hodgkin's disease and reactive hyperplasia. Frozen section immunohistochemistry.
    Author: Martin JM, Warnke RA.
    Journal: Cancer; 1984 Jun 01; 53(11):2450-5. PubMed ID: 6231984.
    Abstract:
    Cryostat sections of lymph nodes from patients with Hodgkin's disease were stained with monoclonal antibodies reactive with T-cells including T-cell subsets. Lymph nodes showing reactive hyperplasia were used as controls. Using an eyepiece grid, the stained cells were counted and subset ratios determined. The ratio of helper T-cells to cytotoxic/suppressor T-cells, i.e., (formula; see text) in Hodgkin's disease was found to be significantly different from ratios obtained from reactive nodes. This difference may be explained by a relative increase in cytotoxic/suppressor T-cells and/or a decrease in helper T-cells. This finding may relate to the previously reported increase in suppressor cell activity in patients with Hodgkin's disease and may also correlate with diminished delayed-type hypersensitivity in such patients.
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