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  • Title: Dysfunctional plasminogen in full term newborn--study of active site of plasmin.
    Author: Benavent A, Estellés A, Aznar J, Martinez-Sales V, Gilabert J, Fornas E.
    Journal: Thromb Haemost; 1984 Feb 28; 51(1):67-70. PubMed ID: 6232730.
    Abstract:
    The functional activity and active site of plasmin in full-term newborns have been studied and compared to those in adults in order to investigate the nature of the abnormality found in newborn plasminogen described in a previous paper. The functional activity of newborn plasminogen measured on chromogenic substrate was approximately 18% that of adult plasminogen when streptokinase was used as an activator and 12% when urokinase was used. Proteolysis of newborn plasminogen by urokinase yielding a two-chain plasmin form occurred normally, but the incorporation of diisopropylphosphorofluoridate into the light chain of newborn plasmin was approximately 23% of that observed in the light chain of adult plasmin. These observations suggest that the abnormality of full-term newborn plasminogen is located in the active site of the molecule.
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