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  • Title: Modifications of the molecular weight of membrane-bound nonspecific beta-glucosidase in type 1 Gaucher disease determined in situ by the radiation inactivation method.
    Author: Maret A, Potier M, Salvayre R, Douste-Blazy L.
    Journal: Biochim Biophys Acta; 1984 May 25; 799(1):91-4. PubMed ID: 6232954.
    Abstract:
    The radiation inactivation method has been used to compare the molecular weight of the nonspecific membrane-bound beta-glucosidase in situ in normal human spleen and in that of two patients with Gaucher disease type 1. We report, in type 1 Gaucher spleen, the presence of a high molecular weight component (557 000) in addition to the normal low molecular weight component (97 800). The various possible hypotheses explaining this high molecular weight component are discussed.
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