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  • Title: Aspirin decreases platelet uptake on Dacron vascular grafts in baboons.
    Author: Mackey WC, Connolly RJ, Callow AD, Keough EM, Ramberg-Laskaris K, McCullough JL, O'Donnell TF, Melaragno A, Valeri CR, Weiblen B.
    Journal: Ann Surg; 1984 Jul; 200(1):93-9. PubMed ID: 6233945.
    Abstract:
    The influence of a single dose of aspirin (5.4-7.4 mg/kg) on platelet uptake on 4-mm Dacron interposition grafts was studied in a baboon model using gamma camera scanning for 111-Indium labeled platelets. In vitro assessment of platelet function after aspirin administration revealed that in the baboon, as in the human, aspirin abolished arachidonic acid-induced platelet aggregation, prolonged the lag time between exposure to collagen and aggregation, and decreased plasma thromboxane B2 levels. Aspirin also prolonged the template bleeding time. Scans for 111-Indium labeled platelets revealed that pretreatment with a single dose of aspirin decreased platelet uptake on 4-mm Dacron carotid interposition grafts. This decrease in platelet uptake was associated with a significant improvement in 2-hour graft patency and with a trend toward improved 2-week patency.
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