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  • Title: Relation between Ca2+-ATPase and endogenous calmodulin of human erythrocyte membranes.
    Author: Klinger R, Wetzker R, Wenz I, Dinjus U, Reissmann R, Frunder H.
    Journal: Cell Calcium; 1984 Apr; 5(2):167-75. PubMed ID: 6234066.
    Abstract:
    Short incubation of erythrocyte membranes with oleic acid releases Ca2+-independently bound endogenous calmodulin together with a minor fraction of membrane-associated proteins without destruction of the membranes. The released endogenous calmodulin is similar if not identical to cytosolic calmodulin reversibly bound to ghosts in a Ca2+-dependent manner. The release of endogenous calmodulin proceeds without affecting the activity of Ca2+-ATPase when ghosts are incubated with oleic acid in the presence of Ca2+ plus ATP and thereafter freed from oleic acid by washings with serum albumin. Kinetic parameters of Ca2+-ATPase of ghosts with and without endogenous calmodulin are identical as are amounts of exogenous calmodulin bound to these ghosts. Thus, endogenous calmodulin does not function as an essential part of Ca2+-ATPase.
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