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  • Title: Changes in serum apo-lipoprotein AI and sex-hormone-binding globulin levels after treatment with two different progestins administered alone and in combination with ethinyl estradiol.
    Author: Crona N, Silfverstolpe G, Samsioe G.
    Journal: Contraception; 1984 Mar; 29(3):261-70. PubMed ID: 6234148.
    Abstract:
    Twenty women, oophorectomized as part of the surgical treatment for cervical carcinoma in either clinical stage IB or IIA but otherwise healthy, participated in the study. After a period of six weeks without hormonal treatment, ten of them were given 150 micrograms desogestrel (DG) daily for three weeks followed by 150 micrograms DG + 30 micrograms ethinyl estradiol (EE) for six weeks and, finally, 30 micrograms EE alone for three weeks. The remaining ten women were given 150 micrograms levonorgestrel (NORG) and EE in a similar regimen. Before treatment and after each period of treatment, apo-lipoprotein AI and sex-hormone-binding globulin (SHBG) were assayed in serum. Both progestins decreased apo-AI and SHBG when given alone, thereby indicating an "androgenic" influence. In combination with EE, however, DG seems to be less "anti-oestrogenic" than NORG, as judged from the higher apo-AI and SHBG values after the combination DG + EE compared to those after NORG + EE. 20 women, oophorectomized as part of the surgical treatment for cervical carcinoma in either clinical stage IB or ITA but otherwise healthy, paticipated in the study. After a 6-week period without hormonal treatment, 10 of them were given 150 mcg desogestrel (DG) daily for 3 weeks followed by 150 mcg DG & 30 mcg ethinyl estradiol (EE) for 6 weeks and, finally, 30 mcg EE alone for 3 weeks. The remaining 10 women were given 150 mcg levonorgestrel (NORG) and EE in a similar regimen. Before treatment and after each treatment period, apo-lipoprotein AI and sex hormone binding globulin (SHBG) were assayed in serum. Both progestins decreased apo-AI and SHBG when given alone, thereby indicating an androgenic influence. In combination with EE, however, DG seems to be less antiestrogenic than NORG, as judged from the higher apo-AI and SHBG values after the combination of DG EE compared to those after NORG & EE.
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