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  • Title: Seminal plasma inhibits lymphocyte response to T-dependent and -independent antigens in vitro.
    Author: Thomas IK, Erickson KL.
    Journal: Immunology; 1984 Aug; 52(4):721-6. PubMed ID: 6235181.
    Abstract:
    The effect of seminal plasma, epididymal spermatozoa, or whole semen on antibody producing cells was examined in vitro after (i) direct culture with spleen or B cells, and (ii) cocultivation of B cells with T cells previously incubated with seminal plasma. Seminal plasma, and not epididymal spermatozoa, have an inhibitory effect on the direct hemolytic plague forming cell response. This was mediated by a direct inhibitory effect on the B cell and not through the generation of suppressor T cells as demonstrated by responses to T-independent and -dependent antigens. Thus, the mode of suppressive action of seminal plasma in vitro is probably different from that previously reported in vivo.
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