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  • Title: Induction of early alloantigen tolerance in thymus and spleen.
    Author: Schwartz DH, Doherty PC.
    Journal: Thymus; 1984; 6(1-2):105-20. PubMed ID: 6235644.
    Abstract:
    Both thymocytes and splenocytes from B6 (H-2b) mice injected as neonates with C3H(H-2k) or (B6 X C3H)F1 cells exhibited specific nonresponsiveness to the H-2KD alloantigens in question. Thus, tolerance could be induced in strain combinations which did not share H-2 antigens. Induction of specific allotolerance did not require the presence of Thy-1.2+, Ia+ or G10-Sepharose-adherent cells in the donor inoculum, however injection of irradiated (1200 rad) cells was ineffective. Evidence of specific unresponsiveness was found as early as 5 days after birth and was not abrogated by adding either irradiated normal spleen cells or exogenous interleukin-2 in vitro. In fact, in some experiments there was evidence for the presence of stimulated helper T cells within the population of 'tolerant' cytotoxic T cells exposed to alloantigen. However, this could reflect the operation of a syngeneic mixed lymphocyte reaction directed at, for instance, fetal calf serum components expressed in the context of the tolerated Ia determinants.
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