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  • Title: Quantitative aspects of membrane shifts in rat parathyroid cells initiated by decrease in serum calcium.
    Author: Wild P, Schraner EM, Eggenberger E.
    Journal: Biol Cell; 1984; 50(3):263-72. PubMed ID: 6235879.
    Abstract:
    The secretory activity of parathyroid glands in rats was stimulated by decreasing the serum Ca++ concentration through constant intravenous infusion of EGTA. The morphometric analysis of the nuclear and cytoplasmic volume and of the surface area of the rough endoplasmic reticulum, Golgi complex, secretory granules and plasma membrane revealed a membrane shift from secretory granules and Golgi complex to the plasma membrane within 1 hr of calcium depression. Subsequently, between 1 and 3 hr of calcium depression, the membrane shift was from the plasma membrane to the Golgi complex. It is considered likely that these membrane shifts are related to a rise in release of parathyroid hormone by exocytosis and a subsequent increase in retrieval of plasma membrane by endocytosis--probably through the compartment of coated pits and coated and uncoated vesicles.
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