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  • Title: Uric acid metabolism in two patients with coexistent Down's syndrome and gout.
    Author: Ciompi ML, Bazzichi LM, Bertolucci D, Mazzoni MR, Barbieri P, Mencacci S, Macchia D, Mariani G.
    Journal: Clin Rheumatol; 1984 Jun; 3(2):229-33. PubMed ID: 6236020.
    Abstract:
    Two patients with coexistent Down's syndrome and gout are described. Although increased serum urate levels are frequently reported in Down's syndrome, only a few such patients have been described with concomitant gout. In our patients no significant alterations of the purine salvage pathway were found, and the turnover parameters of uric acid, determined by means of a 14C-labeled uric acid study, were consistent with the metabolic findings observed in normoexcretor gouty patients.
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