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  • Title: Effect of plasmapheresis on cellular immunity abnormalities in patients with systemic lupus erythematosus.
    Author: Bonomini V, Vangelista A, Frascà GM, Nanni-Costa A, Borgnino LC.
    Journal: Clin Nephrol; 1984 Sep; 22(3):121-6. PubMed ID: 6237815.
    Abstract:
    The effect of plasmapheresis on cellular immunity was studied in 10 patients with active lupus erythematosus (SLE) by evaluating before and after treatment the percentage of E-rosette forming cells (E-RFC), the inhibitory effect of patients' sera on rosette formation by normal lymphocytes, the Con A-induced suppressor activity and T-cell subsets studied by means of monoclonal antibodies. After plasmapheresis a significant improvement was observed in E-rosette formation and in Con A-induced suppressor activity, along with a marked reduction in the inhibitory effect of patients' sera on rosette formation. No change was observed in the number and percentage of T-cell subsets. These findings suggest that plasmapheresis may remove some circulating factors responsible for the immunoregulatory T-cell dysfunction observed in patients with active SLE.
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