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  • Title: Effect of combined topical glucocorticoids and ultraviolet B irradiation on epidermal Langerhans cells.
    Author: Belsito DV, Baer RL, Gigli I, Thorbecke GJ.
    Journal: J Invest Dermatol; 1984 Nov; 83(5):347-51. PubMed ID: 6238103.
    Abstract:
    The combined effect of topical glucocorticoids and ultraviolet B (UVB) irradiation on ATPase+ epidermal Langerhans cells in vivo was investigated in the guinea pig model. Glucocorticoids did not significantly enhance the response to UVB radiation, in the dosage range from 90-550 mJ/cm2 of UVB, suggesting that both agents were acting in a similar fashion. The solvent ethanol, however, potentiated the effect of UVB exposure due, at least in part, to increased penetration of the UVB into the epidermis. The recovery of ATPase+ Langerhans cells was significantly slower after high (greater than 165 mJ/cm2) than after more moderate doses (90-145 mJ/cm2) of UVB radiation.
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