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  • Title: Antibody affinity and acute immune complex disease.
    Author: Griswold WR, Brams M.
    Journal: J Clin Lab Immunol; 1984 Aug; 14(4):181-3. PubMed ID: 6238168.
    Abstract:
    The affinity of anti-BSA antibody was measured daily in rabbits with acute immune complex disease. Affinity values increased with time (r = 0.87: p less than 0.01). Antibody affinity before antigen elimination was 5.3 +/- 0.7 X 10(5)M-1 (Mean +/- SEM, n = 19); affinity after antigen elimination was 9.6 +/- 1.4 X 10(5)M-1 (n = 7). (p less than 0.01: Student's t-test). At the time serum creatinine was elevated antibody affinity was low averaging 7.6 +/- 1.24 X 10(5)M-1 (n = 9). These findings support the hypothesis that complexes of low affinity antibody and antigen may participate in acute immune complex injury.
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