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  • Title: Origin of nitrogen in the biosynthesis of carbamoylpolyoxamic acid.
    Author: Isono K, Crain PF, McCloskey JA.
    Journal: Biomed Mass Spectrom; 1978 Jan; 5(1):89-90. PubMed ID: 623901.
    Abstract:
    The biosynthetic origin of the carbamoylpolyoxamic sidechain of the polyoxin nucleoside peptide antibiotics was studied using 15N labeled alpha-amino-S-hydroxyvaleric acid as precursor. Gas chromatography mass spectrometry of polyoxamic acid isolated from culture filtrates of Streptomyces cacaoi var. asoensis showed incorporation of the nitrogen atom of alpha-amino-S-hydroxyvaleric acid into carbamoylpolyoxamic acid with an isotopic dilution factor of 23, thus establishing the intermediacy of alpha-amino-S-hydroxyvaleric acid and determination of the full biosynthetic pathway.
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