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  • Title: Myocardial lesions in experimental acute heart failure.
    Author: Laky D, Constantinescu S, Filipescu G, Ratea E, Hălălău F.
    Journal: Morphol Embryol (Bucur); 1984; 30(3):223-7. PubMed ID: 6239100.
    Abstract:
    The present study concerns the morphological and biochemical lesional picture of the myocardium in cases of acute heart failure induced by various experimental models: ligature of the coronary artery, direct electric stimulation of the heart by catheterism, lethal hemorrhage, pneumothorax, beta-adrenergic shock. Worthy of note was the similitude of the lesional myocardium pictures characterized electron microscopically by a wide range of lesions, from reversible to focal cytolysis, and biochemically by decrease of mitochondrial enzymes, ATP, Mg2-1 X K+ and increase of Na+ X H2O, Ca2+. Problems linked to the pathogenesis, reversibility of the lesions and efficiency of certain therapeutical means are discussed.
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