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  • Title: Measurement of pulsatile flows and variable volumes by bolus injection of indicator in a model of the pulmonary circulation.
    Author: Zelter M, Polianski J, Douguet D, Sibille L, Mensch-Dechene J, Lockhart A.
    Journal: J Physiol (Paris); 1984; 79(1):22-8. PubMed ID: 6239918.
    Abstract:
    The reliability and accuracy of the bolus injection-dye dilution technique were assessed for a physiological range of frequencies (13-49 min-1) and stroke volumes (60-160 ml) on a glass model where flows and volumes varied as a preset function of time (n = 320). We found that the technique overestimates flow by about 8% with a 95% confidence interval of +/- 10% for one measurement. Mean transit times are accurate within a +/- 7% confidence interval for one measurement. In a time-dependent flow and volume system this technique measures the mean volume as related to time with fluctuations up to +/- 30% around the mean. Results are independent of time and site of injection. The double injection-single sampling technique gives results that are equivalent to those obtained by single injection and sampling of dye.
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