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  • Title: Comparison of Fc gamma-receptors isolated from normal human serum and peripheral blood lymphocytes.
    Author: Sandilands GP, Peel MG, MacSween RN.
    Journal: J Clin Lab Immunol; 1984 Sep; 15(1):39-44. PubMed ID: 6239925.
    Abstract:
    In this study, Fc gamma-receptors were isolated from normal human peripheral blood lymphocytes by prolonged incubation at 37 degrees C and purified by affinity chromatography using Sepharose 4B combined with heat-aggregated IgG. These labile Fc gamma R-receptors were shown to be functionally active with an apparent molecular weight of 60 K. Serum Fc gamma-receptor like molecules were also isolated and were shown to be of similar molecular weight. In addition, a high molecular weight (greater than 19S) serum IgG-binding protein was found. The basic sub-unit structure of this molecule was also 60K suggesting that the Fc gamma-receptor may exist in a polymeric or complexed form in normal human serum.
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