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  • Title: [Rush desensitization to respiratory allergens].
    Author: Bousquet J, Guèrin B, Michel FB.
    Journal: Presse Med; 1984 Dec 08; 13(44):2679-83. PubMed ID: 6240031.
    Abstract:
    Rush desensitization was introduced in 1930 and has been renewed by the advent of standardized, freeze-dried allergens of known and constant quality. It consists of giving rapidly progressive doses of allergens, followed by further injections of maintenance doses. In spite of relatively numerous adverse reactions--but not more than with the conventional method using the same aqueous preparations in the same doses--rush desensitization has proved very useful by providing rapid protection. Its effectiveness against allergy to pollens has been demonstrated by a controlled clinical trial and by responses to challenge tests performed before and after treatment. A decrease in skin reactivity has been noted soon after the maintenance dose is reached. Rush desensitization is accompanied by very slight changes in specific IgE levels and by a moderate but statistically significant increase in specific IgG levels. This method constitutes a suitable alternative to conventional immunotherapy in a substantial number of cases and probably involves different immunoprotective mechanisms.
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