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  • Title: The presence of normal levels of serum immunoreactive insulin-like growth factor 2 (IGF-2) in patients with Down's syndrome.
    Author: Annerén G, Enberg G, Sara VR.
    Journal: Ups J Med Sci; 1984; 89(3):274-8. PubMed ID: 6240148.
    Abstract:
    The present study was performed to further investigate the levels of somatomedins in Down's syndrome (DS). The results show that the serum levels of immunoreactive insulin-like growth factor 2 (RIA-IGF-2) in patients with DS is within the normal adult range. No age variation among the patients was observed. Since we earlier reported a deficiency of immunoreactive insulin-like growth factor 1 (IGF-1) in DS patients, present study showing normal RIA-IGF-2 levels suggests a selective deficiency of IGF-1 in DS.
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