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  • Title: Improved lesion detection with dimethyl-amino-diphosphonate: a report of two cases.
    Author: Smith ML, Martin W, McKillop JH, Fogelman I.
    Journal: Eur J Nucl Med; 1984; 9(11):519-20. PubMed ID: 6240401.
    Abstract:
    In two patients with metastatic disease more lesions were detected on scintigraphs obtained with the 'low uptake' bone-scanning agent dimethyl-amino-diphosphonate. The results in these two patients provide practical support for the suggestion that bone-scanning agents with low uptake in normal bone, but high tumour-to-normal bone ratios, will allow better delineation of focal bone abnormalities.
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