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  • Title: The effect of idiotype-specific and anti-ACA-1 sera on T cell subpopulations responding to H-2 antigens.
    Author: Nesterenko VG, Rubakova EI, Egorova SG, Suslov AP, Abronina IS.
    Journal: Folia Biol (Praha); 1984; 30(5):307-16. PubMed ID: 6240416.
    Abstract:
    A xenogeneic anti-CBA-anti-C57BL/6 idiotype-specific serum reacted specifically only with CBA anti-C57BL/6 T cells. It inhibited T killers, T lymphocytes proliferating in one-way MLC and T cells which take part in the rejection of the cardiac allografts. However, it did not affect T suppressors and T MIF producers. Another antiserum, directed against ACA-1 (activated cell antigen), inhibited T killers of various specificities, but not T suppressors or T MIF producers. These results allow us to suggest that (1) the idiotype-like structures of T suppressors and T MIF producers differ from those of other T cell subpopulations responding to H-2 antigens; (2) ACA-1 is expressed on the surface of T killers, but not on T suppressors or T MIF producers; (3) T cells producing MIF form a separate subpopulation.
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