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  • Title: [Pathogenesis of experimental thyrotoxic myopathy].
    Author: Kazakov VM, Katinas GS, Skoromets AA.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1984; 84(11):1613-8. PubMed ID: 6240878.
    Abstract:
    The data obtained in mice with experimental thyrotoxic myopathy included a decrease in the median diameter of the muscle fibers by 17.1 per cent and various focal degenerative changes in less than 20 per cent of the muscle fibers; a statistically significant elevation in the activity of alpha-glycerophosphate dehydrogenase, as well as a reduction in phosphorylase activity and glycogen levels. There was also a significant diminution in the median diameter of the motor terminal plates, a decrease in cholinesterase activity and intensified collateral ramification of the distal axons. The major cause of the muscular weakness and structural changes in the skeletal muscles in thyrotoxic myopathy seems to lie in lowered cAMP concentrations and a weakened cAMP-dependent regulation of protein kinase.
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