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  • Title: Effect of progestogen (Depo-Provera) on annulate lamellae in endometrial carcinoma.
    Author: Szarvas Z, Zsolnai B.
    Journal: Acta Chir Hung; 1984; 25(4):269-76. PubMed ID: 6240879.
    Abstract:
    The authors studied electron microscopically the effect of a large dose of medroxyprogesterone acetate (Depo-Provera) on the fine structure of endometrial carcinoma, with special regard to the annulate lamellae of the cells. Following treatment in one-third of their cases of highly-differentiated endometrial carcinoma the glandular epithelial cells were found to show a marked regression. After using a large dose of progestogen, the oestrogen-dependent annulate lamellae 'disappeared' from the cytoplasm of the cells. This phenomenon may be one of the morphological manifestations of subcellular oestrogen-progesterone antagonism.
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